KMID : 1034720230150010001
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Journal of Neurosonology and Neuroimaging 2023 Volume.15 No. 1 p.1 ~ p.23
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Advanced Imaging in the Current Era of Acute Reperfusion Therapies
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Klearchos Psychogios
Odysseas Kargiotis Apostolos Safouris Georgios Magoufis Lina Palaiodimou Mariana Papadopoulou Stavros Spiliopoulos Georgios Velonakis Michail Mantatzis Theodore Karapanayiotides Panayiotis Mitsias Georgios Tsivgoulis
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Abstract
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Reperfusion of the ischemic brain parenchyma with intravenous thrombolysis and/or mechanical thrombectomy is the cornerstone of acute ischemic stroke treatment. A paradigm shift from ¡°time is brain¡± to a more precision medicine approach now called ¡°imaging is brain¡±, has taken place during the last decade. This transformation has been fueled by the progress in neuroimaging. Advanced Neuroimaging incorporates perfusion imaging in order to depict real-time cerebral perfusion disturbances and provide maps of the penumbra and ischemic core that will inform individualized clinical decisions. Advance neuroimaging has now a fundamental role in triaging patients that will receive reperfusion treatments beyond the conventional time windows of 4.5 hours for intravenous thrombolysis and 6 hours for mechanical thrombectomy. We provide a narrative review of all the pivotal observational studies and randomized-controlled clinical trials that supported the use of advance neuroimaging, as well as technical issues and pitfalls that may be useful for its implementation in routine clinical practice.
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KEYWORD
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stroke, ischemic stroke, thrombolytic therapy, perfusion imaging, advanced neuroimaging
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